for some reason..

Evilematt: Maybe it's some kind of plasma/hightech/laser-uber-knife with a laserpointer that burns through the skull? :p

EDIT: I have Dead Space installed right now, but I'm stuck on Chapter 3. Some kind of Tentacle draws me into a hole, and I don't have enough ammo to destroy it :(
 
It is possible to put a knife through a skull. Bone might be hard but not that hard that it can stop a metal object with a sharp point. Think of a meat cleaver chopping chops. The point of a knife would have even more power behind it.
 
anyone played dead space yet? theres a bit where a scientist rams a knife into the top of a dudes skull, and you just stand there and calmly watch it happen, my question is.....

can you actually stab someone in the head, as in, put a knife into their skull, is that possible?

A zombie on Dead Set gets stabbed multiple times in the back of the head, all in bone crunching glory.