I love my Saffire Pro 40, except for the fact that I cannot get reamping to work on this fucking thing to save my life.
I'm running out of output 7, with a separate mix made for it. The output is not tied to the Monitor Volume knob at all, yet, when I play any DIs through the output into my X-Amp and into an amp, it's always severely undergained, with a TON of noise. In order to achieve the same level of gain through the amp as I could by just plugging the guitar directly into it, I have to nearly double the gain, and at that point, the thing is feedbacking like mad, so forget turning it up to any decent volume. I've never in my life had so many issues with routing and reamping as I'm having with this thing, it's seriously pissing me off and making me consider getting rid of it to buy a different interface.
The preamps might be super clean, but it's not very user friendly when you start trying to do anything fancy with it. Plus, as far as I know, you can't route the monitor volume knob to the S/PDIF outputs, so I can't control my monitor's volume unless I manually load up Mix Control and adjust the volume fader on the mix I have setup for them (since the monitors are running on digital inputs, because the sound quality is more crisp, plus I like that they go on standby when I turn the interface off), which is a hassle as well.
I have to be doing something wrong on the reamping, but what, I have no idea. It's just pissing me off, because I've been constrained to amp sims for months because of it and having a $4600 amp going unused is pretty useless. Plus, the fact that I have to turn up the gain on the mic preamps to ~7 to even get a decent amount of volume out of them is sort of ridiculous, practically everything below 6 is completely useless on the mic inputs.