Sure, and I use Ownhammer IRs for a number of other amps and patches. I just think the 5150 is well matched with this combo, and the HD500 only had a "Uber" cab model which supposedly incorporated both speakers, and it didn't have a Heil PR30 mic option, nor the option to move it further away, as I did. Like I said...I've had a Pod HD before, and there was no cab I got to sound like that.
No biggie. Just a matter of taste. I quick recorded it, so there is no DI, but it's easy enough to go back in and chug chug with an all-OH assortment of guitar tones. Point is I love the Helix. This nonsense about it only being capable of "scooped" or "fizzy" or "sterile" tone is just that.
Here's another clip of guitar only I did that is all Ownhammer IRs:
Now, you tell me that sounds like a HD500, and I got nothing else to say.