My settings are Treble: 10 Mids:0 Bass:10 Presence:10...
No, there's nothing wrong with my settings. In fact, I keep my mids higher than most people running a 5150 would, around 1:00. The Line 6 just has more prevalent mids/is a lot louder. I haven't put it under a mic yet, this is with us just playing in our rehearsal space with both amps facing similar directions.