This has been my experience: I wanted a Marshall a while back, and I went to the store and tried out every head they sold, and cost was no issue. I literally A/Bd the $1500 stuff against the G100RCD solid state head that costs about $350. I got the cheap one - not the new one with the digital effects, because the reliability on them is crap - but the old version. It has a CD input, if you can believe that. I now have 3 of them because you can buy them on Ebay for about $250 or less used.
I run that head through a Mesa 4x12 and use no pedals for my distortion. I play a Brian Moore i8 with Seymour Duncan JBs. That's the rig that I use most of the time live - and for recording.
I do have also a Spinal Tap custom rig that I built - it's all in a custom rack enclosure and I have a Bogner Uberschall and the Marshall splitting my cab for the heavy tone, and the Marshall for the clean tone. I also have a TC Electronics G-Major and a Digital Audio Corp GCX midi switcher. I have a couple of pedals mounted in the rack for certain effects.
BUT....I use the Marshall through the Mesa by themselves 90% of the time and it sounds killer. The Mesa really brings out the low end in the Marshall head, but it also keeps the high and high mids that Marshall is known for intact. The model for the head is G100RCD.