Well I totally agree about Deathspell Omega. I think Kenose is a really amazing piece of work. If you think about it, they've defied nearly all of the aesthetics and rules of black metal, yet created something that's undeniably black metal. They've tapped into the essence of black metal, rather than just relying on the aesthetics like so many bands do. I can't wait to see what they do next, and unless they screw up badly, their trilogy will go down as one of the most impressive musical works in all of metal. I expect them to do no less.
The Ukrainian metal scene - They're about one more band away from being one of the notable and legendary scenes in metal history. If Roman Saenko's Blood of Kingu ends up being anything really unique, then that would do it.
Agalloch - I haven't even heard the new album yet, but from what people have been saying, it's good. Agalloch could be as big as Opeth, if they want to be. They probably would appeal to the post-rock/indie crowd in ways that no other metal band that I can think of does.
Nile - The Morbid Angel of this generation really. They've pretty much gotten better with each album. Their ability to do link lyrical and musical themes so closely is pretty much unmatched. Some see it as a gimmick, but it's hard to not see the imagery and feel the atmosphere the band intends, a much tougher accomplishment in death metal than black metal.
Leviathan - He just has a ton of great ideas. Probably the best one-man project going now.