Couple of tips for Mac users and PT users in general.
Mac stuff:
Although they are much easier to maintain then pcs you still have to do a few maintenance things to keep it going good. Run Disk Utility on your drives at least one a week. Repair Permissions and check all drives. If you are willing to be thorough, ALWAYS repair permissions before and after you install anything.
Turn off any extra fancy features. Spotlight/Corners, all that ridiculous flashy desktop related stuff. Also, have the least amount of stuff on the desktop. The difference is not much, but it definitely helps.
Watch for other programs running in the background. If you look at the usage meter in utilities, you'd be shocked at how much MSN/Firefox/general internet related stuff slows PT down. Messenger in particular is a killer.
PT STUFF:
If you don't have it yet get this.
http://www.jcdeshaies.com/
Its a permissions/prefs app for pro tools users. It also comes with a great start up program that'll delete those digidesign databases folders at start up. That one thing alone will make assertion errors virtually disappear.
Make sure your Buffers are all set right.
Consolidate all audio tracks. Protools would rather read 1 big file then 10000 little ones.
Dump all unnecessary playlists and REMOVE all unused regions (shift-apple U to select them then shift-apple P to get rid of them) PLEASE DO NOT HIT DELETE.
The removal of unused regions is the number 1 way in PT to speed things up.
Despite Digi's best efforts, PT HATES RTAS instruments....even it's own! Print those files. A Soft Synth in Logic/cubase/nuendo uses considerably less CPU then it does in an identical situation in pt. So don't be fooled.
I'll add more as I think of them....