Castlevania: Lords of Shadow will be released this week and I'm planning to pick it up. Looks great and albeit it looks (a bit) like God of War instead of Castlevania, it's a positive thing. It's good they are taking a bit different route this time, considering how bad previous 3D Castlevanias are.
In three weeks my most anticipated game of the fall will be released and that's Fallout: New Vegas. I'm big fan of the first two and I did enjoy 3rd quite a bit too (despite it's differences and flaws). I'm fairly sure New Vegas will be a great game. Some people who worked on the first 2 are working for Obsidian Entertainment (developer of F:NV) now.
PS. Games I have played lately are StarCrat II, Civilization 5, Red Dead Redemption, Mafia II, F1 2010 and Halo: Reach.