Males and Females
- Thread starter damnromulans
- Start date
Dak
mentat
Disagree. I live in a low class family and i got treated for depression and i'm getting treated for cancer. Health issues should neither be neglected nor procrastinated. If you don't care for your health then that's another issue.
tagradh.
I think we are disagreeing on different things
I thought you were saying it's always possible for people to get treatment for ailments, which is what I disagreed with. Of course people should be taking care of their health.
cookiecutter
Proceed to Ultraslamming
This is good advice. Being in similar places in life is important because you more easily understand and sympathize with what they are doing.
Matt
Active Member
Completely. My mother was a suicidal maniac until she got on them.
But, I'd prefer you just stay miserable. Your long posts about how shitty your life is just makes me feel better about mine.
Krigloch the Furious
Pants full of poo
Chanakya
Orphaned Brother
Master_Yoda77
Juggalo
Cythraul
Active Member
- Dec 10, 2003
- 6,755
- 133
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Mathiäs;9924362 said:
Well, that's nice, but if you can't see how that is not evidence against my position, then it's not even worth discussing this with you.
Except that's not what's happening. Oh hey, I can cite anecdotal evidence too!
I suggest you start educating yourself: http://www.nybooks.com/articles/archives/2011/jun/23/epidemic-mental-illness-why/?pagination=false
Kirsch and his colleagues used the Freedom of Information Act to obtain FDA reviews of all placebo-controlled clinical trials, whether positive or negative, submitted for the initial approval of the six most widely used antidepressant drugs approved between 1987 and 1999—Prozac, Paxil, Zoloft, Celexa, Serzone, and Effexor. This was a better data set than the one used in his previous study, not only because it included negative studies but because the FDA sets uniform quality standards for the trials it reviews and not all of the published research in Kirsch’s earlier study had been submitted to the FDA as part of a drug approval application.
Altogether, there were forty-two trials of the six drugs. Most of them were negative. Overall, placebos were 82 percent as effective as the drugs, as measured by the Hamilton Depression Scale (HAM-D), a widely used score of symptoms of depression. The average difference between drug and placebo was only 1.8 points on the HAM-D, a difference that, while statistically significant, was clinically meaningless. The results were much the same for all six drugs: they were all equally unimpressive. Yet because the positive studies were extensively publicized, while the negative ones were hidden, the public and the medical profession came to believe that these drugs were highly effective antidepressants.
Kirsch was also struck by another unexpected finding. In his earlier study and in work by others, he observed that even treatments that were not considered to be antidepressants—such as synthetic thyroid hormone, opiates, sedatives, stimulants, and some herbal remedies—were as effective as antidepressants in alleviating the symptoms of depression. Kirsch writes, “When administered as antidepressants, drugs that increase, decrease or have no effect on serotonin all relieve depression to about the same degree.” What all these “effective” drugs had in common was that they produced side effects, which participating patients had been told they might experience.
It is important that clinical trials, particularly those dealing with subjective conditions like depression, remain double-blind, with neither patients nor doctors knowing whether or not they are getting a placebo. That prevents both patients and doctors from imagining improvements that are not there, something that is more likely if they believe the agent being administered is an active drug instead of a placebo. Faced with his findings that nearly any pill with side effects was slightly more effective in treating depression than an inert placebo, Kirsch speculated that the presence of side effects in individuals receiving drugs enabled them to guess correctly that they were getting active treatment—and this was borne out by interviews with patients and doctors—which made them more likely to report improvement. He suggests that the reason antidepressants appear to work better in relieving severe depression than in less severe cases is that patients with severe symptoms are likely to be on higher doses and therefore experience more side effects.
To further investigate whether side effects bias responses, Kirsch looked at some trials that employed “active” placebos instead of inert ones. An active placebo is one that itself produces side effects, such as atropine—a drug that selectively blocks the action of certain types of nerve fibers. Although not an antidepressant, atropine causes, among other things, a noticeably dry mouth. In trials using atropine as the placebo, there was no difference between the antidepressant and the active placebo. Everyone had side effects of one type or another, and everyone reported the same level of improvement. Kirsch reported a number of other odd findings in clinical trials of antidepressants, including the fact that there is no dose-response curve—that is, high doses worked no better than low ones—which is extremely unlikely for truly effective drugs.
lolwut.
Methinks you missed some of what I said. I've tried more antidepressants than anyone I know and had several psychiatrists and the like.
brooks55
Elixir of Sorrow
There's a shitstorm brewing.
Can I assume from this post that you have checked out Trailer Park Boys now?
Onder
Active Member
- Apr 10, 2006
- 11,389
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You just complain all the time dude. You can‘t be mad at me because I don‘t read all those litanies. I mean, I want to be in a good mood and I have never been to such a far dimension of problems. I‘m scared to enter it like this, unprotected.
EDIT: I mean, I don‘t take any fucking pills, I‘m just a normal guy who‘s happy to take a tram to fucking school. I‘m scared of your shit, dude.
Matt
Active Member
It seems to me that dismissing something because it's been called into question is fairly ridiculous.
By the way, the amount of people riding Cythraul's dick on this forum is hilarious. It's just like when Dodens still posted regularly and was a huge ass all the time. Everyone was too scared to comment on how much of a tool he was for some reason.
Master_Yoda77
Juggalo
Dak
mentat
King Richard
Hello there
I could get a good look at a t-bone by sticking my head up a bull's ass, but I'd rather take the butcher's word for it.
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