Oh yes, just played with the Marshall sim for about an hour and I gotta say it's really amazing. Combined with a tubescreamer with drive to 0 to tighten it up it sounds very in-your-face and the picking attack feels really great and tight. Excellent for thrash!
> TSE 808 v2.0.1 (Drive to 0, Tone 4, Volume 5)
>> Thermionik Marshland 800 (Gain 6, Bass 6, Mid 3, Treble 4.5, Presence 8)
>>> NadIR loaded with Rosen Digital Mesa Rectifier Cab
>>>> Waves C4 with just a little low-mid compression
>>>>> awesome!