Well, I've been using what you have for years (I have always wanted to upgrade, but I'm poor as fuck being a university student, massively in debt thanks to student loans), but I've found a good Halo Of Blood tone using the Marshall JCM model on POD Farm. I've actually always been using it even before HOB was released because I liked the way it sounded. I never used the screamer pedal, because they muddy up my tone. I use ALMOST the same one for originals (only difference is I use a little less gain), but for covers, you can hear the sound here. Listen in headphones to hear the full sound.
All Twisted
For leads (only for originals), I use the Solo 100 head without a screamer because I find those muddy up my tone (but I'll actually double check later after I'm off class as to whether I use the pedal boost because I forget). I found out that when I tweaked the Solo 100 Head enough when I was using my old Alexi-200 with Blackouts installed, I got a pretty good Hatebreeder-ish sounding lead tone. I've since sold that guitar and use an Alexi-600 with the EMG ALX-ABQ now. I still use that same lead tone, but because of the different pickups, the tone sounds a little brighter now, and just a smidgeon treblier. I want to say it's a little more FTR-ish sounding?
I dunno, but I stick with the same cover tone with the JCM for all of my Halo covers, including solos just because it works.