Good question. The most serious threat to modern man, it would seem , is not physical annihilation, but the alleged meaninglessness of life. This latent vacuum becomes manifest in a state of boredom. Automation will lead to more and more free time and many will not know how to use their leisure hours.
This is evidenced today by what Dr. Frankl refers to as Sunday neurosis, the depression that afflicts people who become conscious of the lack of content in their lives when the rush of the busy life stops. Nothing in the world helps man to keep healthy as much as the knowledge of a life task. Nietzche wisely said, "He who knows a Why of living surmounts every How".