The tone stack needs sucks the life out of the signal. Sometimes as much as 20db can be lost. since the tone stack messes with the frequency, impedance plays a big role in how it reacts. A cathode follower can drive the tone stack with its very low output impedance, hence why they are favored in a lot of amps. Sometimes a tube buffer after the loop is implemented. Sometimes strange driver stages are used, like in the 5150, that I still don't understand. Some amps have the tone stack right after the input stage, where its easy to implement.
All this becomes much more difficult when you have lots of cascaded gainstages. Somehow I managed to make a 6 gainstage amp that drives the tonestack fine. No crazy CF or buffers used. I will say that the tone stack really likes it when the FX loop gets activated, it must be acting as a buffer so you get a little boost.
There is a lot more too it, but you get the idea. Best thing to do is read a lot of books, like the Kevin O'Connor TUT series, Merlin Blencowe's preamp book is great, and all the richard Kuehnel stuff is good.