by the way....
I thought the mid range was the key as well, but!!!! its not simple like that, mid range can overpower the rest of the song and make it sound very muddy, I think you'll find Anders doesn't push the mids at all, if anything, it is scooped, just because you use scooped mids doesn't mean you sound like metallica, as that is only one part of the sound..
One other thing ...
Distortion can be provided through the AMP, effect pedal or Guitar, but a Les Paul will sound completely different to a Fender Strat even with loads of distortion, Les Pauls tend to been thicker in sound, whilst Fender Strats are more glassy and vibrant, I prefer the Les Paul sound, but thats because they work better for dark heavy rock, due to the twin humbucker pickups... not saying that Fenders are not heavy, The Smashing Pumpkins wrote some heavy stuff on fenders but their sound was different entirely.. True distortion is acheived through Valves and a decent amp will have these in, lots of amps try to emulate this and some get very close, but ultimately Valves (or tubes as the americans incorrectly refer to them as) are the ones to use.