It's worth noting that the Damien and Ghandi cabinets (Marshall 2x12 and Mesa Standard 4x12, respectively) are among the darker cabinets in the collection. That being said, the "cap" positions of both should offer plenty of high end. We chose these cabinets for the demo because they have the most defined, full bass response (great for low tunings and brutal riffing), as well as a nice smooth top end (great for leads.)
Experimentation with your preamp EQ, as well as post EQ in your DAW should get you where you're looking to be tone-wise.