Wanted is that all the world's super-villains decided to band together in 1986 and use their vast collective powers — including mad science, magic and mind control — to eliminate all the world's superheroes and rewrite reality in a darker image. Prior to this the world was a brighter, more hopeful place. Superheroes are only remembered as vaguely as fiction (as they are in the real world), and behind the scenes a cabal of the leading super-villains runs the entire world.
Milquetoast office drone Wesley Gibson discovers that his recently-assassinated father was a super-criminal called The Killer, and that Wesley has inherited his perfect aim and uncanny skill with any weapon. Wesley enters a new life, and must deal with the most dangerous and powerful people in the world — whose ranks now include Wesley himself. After being approached by the Fox, another super-villain, Wesley quits his job and joins the Fraternity, the super-villain society's moniker. Wesley goes through a period of training, in which he is desensitized to violence and given licence to fulfill every desire, including rape (which is referenced but not actually depicted), racially motivated violence and random murder. He then goes on to sever the last connection to his previous life by breaking up with his girlfriend, knowing she cheated on him with his best friend, whom he has already killed. Wesley becomes the bodyguard of the super scientist Professor Seltzer, who is a member of the Five, the leading council of the Fraternity.
At a council meeting, the main antagonist, Mister Rictus, calls a vote that the Fraternity come forward as the ruling body of the Earth, which is defeated narrowly, thanks to the hypnotic manipulation of the Emperor, the swing vote, by Professor Seltzer. Mister Rictus, tired of hiding in the shadows and of controlling only Australia (a nod to Superman II), has Professor Seltzer executed and marks the Fox and Wesley for death. Wesley strikes back after infiltrating the Fraternity's North American headquarters, killing many of the villains as well as Mister Rictus. After killing him, Wesley finds his father alive and well. The original Killer explains that he faked his death and got Wesley to join the Fraternity to make Wesley into a man. He explains Wesley's childhood was essentially carried by his mother, who encouraged him to never fight under any circumstances, knowing that his instincts as the Killer would come forward. After telling Wesley of instances where he'd visit Wesley as he slept, he asks Wesley to kill him, explaining that he's getting old and slow, that he missed a target at under a half mile. Wesley obliges after resisting, and tells the Fox that he's returning to his former life of misery and oppression, not wanting to die like his father. After expressing incredible disbelief, the Fox realizes he's joking, and they depart back to former headquarters of Professor Seltzer, now under his partial leadership. Similar to the film, the end of the comic breaks the fourth wall with Wesley addressing the audience, contemptuously calling them out about their pathetic lives, succinctly ending with: "This is my face while fucking you in the ass."[