The thing is, they do know. the person who first created synthetic cannabanoids stated that just because they were analogs of cannabanoids did not mean they were as safe as the real thing, or safe AT ALL. he predicted people would take them, do stupid things, and kill themselves.
if i were you i wouldnt try any of the 2C compounds. they are more safe than their close relatives, psychedelic amphetamines such as D.O.B and all of it's cousins brothers and sisters, but are still not safe. because LSD is safe, it has lead to the widespread assumption that most research chemicals you can "trip" off are safe as well. its just tripping, right? drink everything you keep under your kitchen sink and i'll bet youll trip too, that's all i have to say about the 2C's.
i've done every drug youve ever heard of and many you havent, been struggling with a heroin and pill addiction for almost two years on top of that, and i still consider "alternative" psychedelics some of the most toxic and dangerous drugs in existence. i've come closer to death from several of these that i have from any amount of heroin i've done.